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Nucleic Acid Therapeutics

The sequencing of the human genome and the elucidation of many molecular pathways that are important in disease have provided unprecedented opportunities for the development of new nucleic acid therapeutics. The types of molecules in development are increasingly varied and include single stranded oligonucleotides like antisense siRNA and various modified RNA oligonucleotides as well as catalytic oligonucleotides like ribozymes; double-stranded RNAs that work through the dicer pathway; immunostimulating oligonucleotides that work by stimulating innate immunity; aptamers that work by binding to proteins and modifying their functions; and transcription factor decoys.

Dionex is a leading provider of turnkey HPLC platforms and innovative column chemistries for therapeutic nucleic acid separations and analytical solutions that address every facet of nucleic acid therapeutics R&D and QA/QC challenges to ensure safe therapy.

Learn about our Nucleic Acids Therapeutics Application Notebook, or browse our applications under the Related Literature tab above.