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Nucleic Acid Analysis

Recent developments in oligonucleotide research have established the potential utility of oligonucleotides as therapeutic agents, particularly in the treatment of cancer, AIDS, and other diseases. Therapeutic oligonucleotides include triplex DNA, transcription factor decoys, antisense DNA/RNA, ribozymes, PNA, 2',5'-oligoadenylates, RNAi, and CpG immune-stimulating oligomers, diagnostic oligonucleotide chips (DNA chips), and gene therapy vectors. The detection, characterization and quantification of incomplete synthesis, modified or improperly synthesized oligonucleotides is regarded as essential for demonstrating safety and efficacy of these molecules and is required by FDA and other regulatory agencies.