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MAbPac HIC Family

The Thermo Scientific™ MAbPac™ HIC column family is designed for separations for monoclonal antibodies (mAbs) and related biologics by hydrophobic interaction chromatography (HIC). Their unique column chemistry provides high resolution, excellent biocompatibility, and complementary selectivity suitable for a broad range of assays for mAbs and related substances.

MAbPac HIC Column Selection Guide

ColumnMAbPac HIC-10MAbPac HIC-20MAbPac HIC-Butyl
Intact mAbs/Proteins++++

+++

++

mAb Aggregates++++

+++

++

mAb Fragments 
(Fab and Fc)
+++

++++

+++

Oxidized mAbs+++

++++

+++

ADCs++++++++++
Bispecific mAbs+++++++++

MAbPac HIC-10 Monoclonal Antibody Analysis Column

A hydrophobic interaction column designed specifically for monoclonal antibody (mAb) analysis including the separation of intact mAbs, mAb aggregates, and fusion proteins.

MAbPac HIC-20 Monoclonal Antibody Analysis Column

The Thermo Scientific™ MAbPac™ HIC-20 column is a high-resolution, silica column designed for separation of monoclonal antibodies (mAbs), mAb fragments, and oxidized variants using hydrophobic interaction chromatography (HIC). The unique chemistry provides high resolution and excellent selectivity.

MAbPac HIC-Butyl Monoclonal Antibody Analysis Column

A high-resolution, polymeric-based hydrophobic interaction column (HIC) designed specifically for monoclonal antibody (mAb) analysis including the separation of antibody drug conjugates (ADCs).